FIG 1.
Anamnestic response to rDEKnull. Mice were primed twice 3 weeks apart with either rDEKnull or rSal1 (control), and their serum anti-DEKnull IgG titers were determined (day 42). Antibody titers were allowed to decline by ∼50% (day 217). Mice from each group were boosted on day 224 with a naturally occurring rDBPII allele (Sal1, 7.18, or P), rDEKnull, or rMSP1-19, and their serum anti-DBPII IgG titers were again determined on day 245 (final blood collection). Bars represent the mean antibody titers (EU) for reactivity of immune sera from each group at a 1 × 105 dilution against the boosting antigen for that group. Error bars represent standard errors.