TABLE 3.
Resistance of mice vaccinated with recombinant proteins of S. zooepidemicus strain NC78 (ST-307) to intraperitoneal challenge with S. zooepidemicus strain 738-09 (ST-315) from outbreak of hemorrhagic pneumonia in shelter dogs in Pennsylvania
| Protein(s) | Challenge (CFU/mouse)a | No. of survivors/total no.b | Resistance (%) | Pc | Antibody titer(s) |
|---|---|---|---|---|---|
| SzM | 106 (female) | 5/10 | 50 | <0.1 | >1:51,200 |
| SzM + SzP | 105 (male) | 8/10 | 80 | <0.02 | SzM, >1:25,600; SzP, 1:12,800 |
| HylC + ScpC | 106 (female) | 9/10 | 90 | ≤0.01 | HylC, 1:25,600; ScpC, 1:51,200 |
| Control | 106 (female) | 0/5 | 0 |
a
Challenge CFU administered to male mice were lower than those administered to female mice based on the previously determined greater susceptibility of male mice to intraperitoneal inoculation of S. zooepidemicus (10).
b
Eight days postchallenge.
c
For difference in morbidity between vaccinated and control mice.