Comparison of the organization of subtilomycin gene clusters with biosynthetic gene clusters of Pep5 group lantibiotics, epilancin 15X (39), epilancin K7 (40), epicidin 280 (24), and Pep5 (41). Genes are labeled differently depending on the predicted function of their products: precursor peptides (black), proteases (horizontal stripes), modification enzymes (vertical stripes), immunity (white), and transporters (gray). The unavailable sequences in strain K7 are shown as a broken line.