Quantification of candidate division TM7 bacteria in plaque samples expressed as percentage of total bacterial 16S rRNA gene copies present. Means for 20 subjects at four treatment time points (T0, T1, T2, T3) for each site of plaque collection (band, bond, elastic, and nonelastic) were calculated. Error bars are ±SEM. There were statistically significant (P < 0.05) changes in proportions of candidate division TM7 sequences associated with orthodontic bond plaque during the orthodontic treatment.