TABLE 1.

Nonribosomal A domain specificity codes, substrate specificities, and categories of selected fungal adenylate-forming reductases

Reductase	Nonribosomal codec	Substrate	Reductase domain type	Reductase family
Candida albicans Lys2	DPRHFVMIKK	l-α-Aminoadipic acida	SDR	α-Aminoadipic acid reductase (class I)
Ceriporiopsis subvermispora Nps3	DPRHFVMIPK	l-α-Aminoadipic acida	SDR	α-Aminoadipic acid reductase (class I)
Dichomitus squalens Lys2	DPRHFVMIPK	l-α-Aminoadipic acidb	SDR	α-Aminoadipic acid reductase (class I)
Fomitopsis pinicola Lys2	DPRHFVMLPK	l-α-Aminoadipic acidb	SDR	α-Aminoadipic acid reductase (class I)
Heterobasidion annosum Lys2	DPRHFVMIPK	l-α-Aminoadipic acidb	SDR	α-Aminoadipic acid reductase (class I)
Phlebia brevispora Lys2	DPRHFVMIPK	l-α-Aminoadipic acidb	SDR	α-Aminoadipic acid reductase (class I)
Punctularia strigosozonata Nps2	DPRHFVMIPK	l-α-Aminoadipic acidb	SDR	α-Aminoadipic acid reductase (class I)
Saccharomyces cerevisiae Lys2	DPRHFVMVKK	l-α-Aminoadipic acida	SDR	α-Aminoadipic acid reductase (class I)
Stereum hirsutum Lys2	DPRHFVMIPK	l-α-Aminoadipic acidb	SDR	α-Aminoadipic acid reductase (class I)
Trametes versicolor Nps4	DPRHFVMIPK	l-α-Aminoadipic acidb	SDR	α-Aminoadipic acid reductase (class I)
Aspergillus flavus LnaA	DVFAFGAIFK	l-Tyrosinea	SDR	Tyrosine reductase (class II)
Aspergillus flavus LnbA	DVFAFGAIFK	l-Tyrosinea	SDR	Tyrosine reductase (class II)
Pleurotus ostreatus Nps1	DILFVGAVLK	Unknown	SDR	Tyrosine reductase (class II)
Trichoderma virens EHK23193	GFLMGGL--S	Unknown	SDR	Aryl acid reductase (class III)
Trichoderma reesei XP_006964071	GFLLGGL--S	Unknown	SDR	Aryl acid reductase (class III)
Aspergillus nidulans XP_664048	GFVMTGH--S	Unknown	SDR	Aryl acid reductase (class III)
Aspergillus terreus ATEG_03630	GFVMLGH--S	5-Methyl orsellinic acid	SDR	Aryl acid reductase (class III)
Gloeophyllum trabeum EPQ54396	GFLLAGH--S	Unknown	SDR	Aryl acid reductase (class III)
Agaricus bisporus XP_006462975	GFMLVGH--S	Unknown	SDR	Aryl acid reductase (class III)
Moniliophthora roreri ESK96610	GFLLAGH--S	Unknown	SDR	Aryl acid reductase (class III)
Stereum hirsutum EIM84978	AMCFTAF--T	Unknown	SDR	Aryl acid reductase (class III)
Aspergillus clavatus XP_001275157	DMWIAACIIK	Unknown	FNR	Serine reductase (class IV)
Aspergillus fumigatus XP_001481395	DMWIAACIIK	Unknown	FNR	Serine reductase (class IV)
Coprinopsis cinerea Nps3	DFWFVAAIAK	Unknown	FNR	Serine reductase (class IV)
Ceriporiopsis subvermispora Nps1	DMWIAASIVK	l-Serinea	FNR	Serine reductase (class IV)
Dichomitus squalens Nps1	DMWIAASIVK	Serineb	FNR	Serine reductase (class IV)
Fomitiporia mediterranea Nps1	DMWIAASIVK	Serineb	FNR	Serine reductase (class IV)
Fusarium oxysporum EXM16769	DMWIAACIVK	Unknown	FNR	Serine reductase (class IV)
Moniliophthora roreri ESK95034.1	DMWIAACIVK	Unknown	FNR	Serine reductase (class IV)
Phlebia brevispora Nps1	DMWIAASIVK	Serineb	FNR	Serine reductase (class IV)
Phanerochaete carnosa NpsX	DMWIAASIVK	Serineb	FNR	Serine reductase (class IV)
Stereum hirsutum Nps3	DMWIAASIVK	Serineb	FNR	Serine reductase (class IV)
Trametes versicolor Nps7	DMWIAACIVK	Unknown	FNR	Serine reductase (class IV)
Trichoderma virens EHK20896	DMWIAACIVK	Unknown	FNR	Serine reductase (class IV)

^aExperimentally confirmed.

^bDeduced by identity of nonribosomal codes.

^cCodes were determined manually by comparison of MAFFT alignments with the PheA protein of Brevibacillus brevis (23).