TABLE 1.
Conformational stabilities of purified PrPSc and rPrP fibrilsa
| Strain | [GdnHCl]1/2 (mol/liter) |
|||
|---|---|---|---|---|
| Purified PrPSc | rPrP fibrils |
|||
| 1st | 2nd | 5th | ||
| Chandler | 3.3 ± 0.4** | 3.3 ± 0.1* | 3.7 ± 0.1 | 3.3 ± 0.3 |
| 22L | 1.7 ± 0.3 | 2.3 ± 0.6 | 3.8 ± 0.2 | 3.5 ± 1.0 |
| Spontaneous | >5 | |||
a
The [GdnHCl]1/2 values (mol/liter) are means ± standard deviations from three independent experiments. Statistical significance was determined using one-way ANOVA, followed by Student's t test. **, P < 0.01 (compared with 22L); *, P < 0.05 (compared with 22L).