TABLE 3.
Evolution of the entire genome sequences of the 5 virus strainsa
| Region | Nucleotide position(s) | Nucleotide/corresponding amino acid(s) from strain: |
||||
|---|---|---|---|---|---|---|
| TLS-09/M0 | TLS-09/M12 | TLS-09/M24 | TLS-09/M36 | TLS-09/M48 | ||
| Me-transferase | 589 | G/Val | R/Val-Ile | G/Val | G/Val | G/Val |
| Me-transferase | 647 | A/Asn | A/Asn | A/Asn | A/Asn | R/Asn-Ser |
| Me-transferase | 695 | M/His-Pro | M/His-Pro | A/His | A/His | M/His-Pro |
| Y domain | 730 | M/Pro-Thr | M/Pro-Thr | A/Thr | A/Thr | M/Pro-Thr |
| Y domain | 778 | M/Ile-Leu | M/Ile-Leu | A/Ile | A/Ile | M/Ile-Leu |
| Y domain | 788 | M/His-Pro | M/His-Pro | A/His | A/His | M/His-Pro |
| Y domain | 896 | C/Ser | Y/Ser-Leu | C/Ser | C/Ser | C/Ser |
| Y domain | 1006 | T/Phe | T/Phe | T/Phe | Y/Leu-Phe | T/Phe |
| PPR | 2168 | C/Ala | C/Ala | S/Ala-Gly | C/Ala | C/Ala |
| PPR | 2474 | T/Leu | T/Leu | T/Leu | T/Leu | C/Pro |
| PPR | 2476 | A/Thr | A/Thr | A/Thr | A/Thr | G/Ala |
| PPR | 2495 | C/Val | C/Val | C/Val | C/Val | T/Ala |
| PPR | 2500 | G/Glu | G/Glu | R/Glu-Lys | G/Glu | G/Glu |
| PPR | 2301–2376 | Insertion | ||||
| X domain | 2573 | Y/Val-Ala | Y/Val-Ala | Y/Val-Ala | Y/Val-Ala | T/Val |
| X domain | 2686 | C/His | C/His | Y/His-Tyr | C/His | C/His |
| Helicase | 3040 | A/Ile | R/Ile-Val | R/Ile-Val | R/Ile-Val | G/Val |
| RdRp | 4147 | A/Thr | A/Thr | A/Thr | A/Thr | R/Thr-Ala |
| RdRp | 4943 | G/Arg | G/Arg | G/Arg | G/Arg | R/Gln-Arg |
| P domain | 6730 | G/Trp | T/Cys | G/Trp | G/Trp | G/Trp |
a
Sequences from the complete genome were aligned and analyzed. PPR, polyproline region; Me-transferase, methyl transferase; PCP, papain-like cysteine protease; RdRp, RNA-dependent RNA polymerase. Bold entries represent nonsynonymous mutations.