FIG 7.

Impact of coinfection on viral clearance and systemic inflammatory mediators. (A) Lung titers of infectious virus at days 3, 7.5, and 10 after PR8 infection in indicated groups (n = 5 to 12 mice/group) were determined by MDCK titer assay. Significance was determined by Mann-Whitney test and two-part test. ns, nonsignificant; *, P < 0.05; bd, below detection. (B) Cytokines in sera from naive, infected, and coinfected mice (day 10 p.i. with PR8) (n = 3 to 9 mice) were analyzed by multiplex assay. Significance was determined by Student's t test. ns, nonsignificant; **, P < 0.01; ***, P < 0.001.