TABLE 1.

Compounds that inhibit HIV-1 fusion by greater than 50%

Compound	% inhibition at 100 μM	Published mechanism	References
NF279	95	Suramin analogue with high selectivity for P2X over P2Y receptors; selective for P2X1 and P2X7 over other P2X receptors	21, 54–56
Suramin	95	Broad-spectrum P2 inhibitor; also blocks calmodulin binding to recognition sites and G protein coupling to G-protein-coupled receptors	37, 57–59
PPNDS	75	PPADS analogue with enhanced selectivity toward P2X1	60–63
NF023	68	Suramin analogue with enhanced selectivity for P2X over P2Y; selectivity toward P2X1	59, 64, 65
PPADS	38	Broad-spectrum P2 Inhibitor	12, 66, 67