FIG 6.
Integration in the vicinity of consensus Rep-binding sites (RBS). (A) AAVwt integration site distribution with reverse (cap-rep) or forward (rep-cap) orientation of the AAVwt genome, in relation to the orientation of GAGC repeats in 1-kb bins around a genomic consensus RBS defined as (GAGC)4, allowing two mismatches. (B) Percentage of AAV integration sites in the vicinity of (GAGY/C)n. Distances from the RBS in intervals from 1 kb up to 50 kb are indicated. (C) Enrichment of AAVwt over random control sites in the vicinity of (GAGC)n. Values are reported as the proportion of AAVwt integration events divided by the proportion of integration events of random controls. Distances from RBS are given in intervals up to 1, 2, 5, 10, 20, and 50 kb, as indicated by black triangles.