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. 2014 Oct;88(19):11130–11139. doi: 10.1128/JVI.01564-14

FIG 6.

FIG 6

Pathogenicities of recombinant viruses with the V14A substitution in LP PB1 for chickens. (A and B) Survival plots for chickens infected with LP or LP-PB1-V14A (A) and for chickens infected with WB(L/PB1) or WB(L/PB1-V14A) (B). The survivability of chickens (n ≥ 4) was determined, and Kaplan-Meier survival rate curves were plotted and were analyzed by the log rank test. (C to F) Viral titers in tracheal (C and D) and cloacal (E and F) swabs from chickens infected with LP or LP-PB1-V14A (C and E) and from chickens infected with WB(L/PB1) or WB(L/PB1-V14A) (D and F). Swabs were collected at 3, 5, 7, and 10 dpi routinely and upon the deaths of the chickens. Viral titers at 1 dpi were those obtained in the experiment reported in Tables 5 and 6. Viral titers at each time point were analyzed by Welch's t test. Asterisks indicate P values of <0.05.