FIG 3.

Primed peptide-specific CD8⁺ T cells show distinct cross-reactivity patterns. (A) Examples of cross-reactivity of CD8⁺ T cells primed with either gt1b_3 (left) or gt1b_AD (right) with all other epitope variants upon restimulation after 28 days. CD8⁺ T cells primed with gt1b_3 were cross-reactive with other genotype 1b epitope variants, whereas CD8⁺ T cells primed with gt1b_AD were not cross-reactive. (B) Summary of the cross-reactivity profiles from all priming experiments. The results of 9 to 11 independent experiments utilizing cells of different donors are shown.