Proposed model for the trafficking of P7-1 tubules in vivo in its insect vector, WBPH. Virus-containing P7-1 tubules pass across the basal lamina from the initially infected midgut epithelium, traffic along the internal circular muscle tissues, and then spread through the external longitudinal muscle tissues. bl, basal lamina; me, midgut epithelium; mv, microvilli; cm, circular muscle; lm, longitudinal muscle; N, nucleus.