FIG 3.

Sequence alignment of motif III of pUL12 homologs conserved in members of the three herpesvirus subfamilies. HSV-1 pUL12 Tyr-371 and the corresponding residues of other herpesviruses are boxed and indicated by an arrow. pUL12 and pUL12 homolog sequences are labeled with their NCBI gene identification numbers and virus names. HSV-2, herpes simplex virus 2; VZV, varicella-zoster virus; BHV-1, bovine herpesvirus 1; EHV-1, equine herpesvirus 1; PRV, pseudorabies virus; HCMV, human cytomegalovirus; HHV-6, human herpesvirus 6; HHV-7, human herpesvirus 7; EBV, Epstein-Barr virus; KSHV, Kaposi's sarcoma-associated herpesvirus; HVS, herpesvirus saimiri; EHV-2, equine herpesvirus 2; GHV-2, gallid herpesvirus 2. HSV-1, HSV-2, VZV, BHV-1, EHV-1, and PRV are in the subfamily Alphaherpesvirinae; HCMV, HHV-6, and HHV-7 are in the Betaherpesvirinae; and EBV, KSHV, HVS, EHV-2, and GHV-2 are in the Gammaherpesvirinae.