TABLE 2.
LD50 values of recombinant HSV-1 strains in mice following intracerebral inoculation
| Virus | LD50 (PFU)a |
|
|---|---|---|
| Expt 1 | Expt 2 | |
| YK655 (ΔUL12) | 105.2 | |
| YK656 (ΔUL12-repair) | 101.8 | |
| YK665 (UL12G336A/S338A) | 103.5 | 103.5 |
| YK666(UL12GA/SA-repair) | 101.5 | 101.5 |
| YK660 (UL12Y371F) | 103.8 | |
| YK661 (UL12Y371F-repair) | 101.5 | |
| YK662 (UL12Y371E) | 101.8 | |
a
Three-week-old female ICR mice were infected intracranially with 10-fold serial dilutions of each of the indicated viruses in groups of 3 per dilution; mortality was monitored for 14 days; and LD50 values were calculated.