FIG 3.

Reduced replication and spread of VSV28.1 following intranasal infection of mice. (A and B) Mice were intranasally infected with 1 × 10⁶ PFU of VSVGFP.1 or VSV28.1. The lungs and spleen were harvested, and viral genomic RNA (VSV-N) (A) or viral titers (B) were quantified by quantitative RT-PCR or by a plaque assay, respectively. (C and D) Mice were left uninfected or intranasally infected with 1 × 10⁶ PFU of VSV or its UV-inactivated equivalent (C) or 1 × 10⁶ PFU of VSV, VSVGFP.1, or VSV28.1 (D). Average weight loss was measured daily until mice had recovered. Error bars represent the standard errors of the means (n = 5). *, P < 0.05; **, P < 0.01.