FIG 1.

The PI3K binding site on MT is essential for efficient transformation in a polyomavirus MT-driven prostate cancer model. (A) Hematoxylin-eosin staining of formalin-fixed prostate tissue from mice with the indicated genotypes at different ages. (B) Relative wet weight of ventral and dorsolateral prostate lobes from mice with the indicated genotypes at different ages. Shown are mean values and standard errors of the means for at least 5 mice per genotype. MT, polyomavirus middle T antigen; MT Y315F, p85 binding-defective MT; ns, not statistically significant; *, P < 0.05; **, P < 0.001.