FIG 5.

Interferon-induced Ifit2 suppresses VSV replication in sciatic nerves after footpad infection. (A and B) Ifit2 mRNA (A) and VSV-N RNA (B) levels in popliteal lymph nodes and sciatic nerves of wt, Ifit2^−/−, and IFNAR^−/− mice, 1 day after infection, as measured by real-time RT-PCR (four to six infected mice per group). (C) VSV-N RNA levels in wt and Ifit2^−/− sciatic nerves, measured by real-time RT-PCR. All VSV RNA levels were plotted on log scale. Asterisks indicate statistical significance (***, P = 0.0007; **, P < 0.003). Dashed lines indicate the threshold of detection.