FIG 8.

VSV infection spreads to all regions of the brain. (A and C) VSV-N RNA levels in different regions of the brains of paralyzed mice. (A) Four Ifit2^−/− mice, numbered 1 to 4, after infection with 10⁶ PFU of VSV; (C) six wt mice, numbered 1 to 6, after infection with 3.5 × 10⁷ PFU of VSV. (B) Hind-limb paralysis of wt mice after footpad injection of 10⁶ PFU (from Fig. 1) or 3.5 × 10⁷ PFU of VSV (n = number of animals). No significant difference in RNA levels was found between respective wt and Ifit2^−/− brain regions in panels A and C. The dashed lines in panels A and B indicate the threshold of detection.