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. 2014 Sep;88(18):10511–10524. doi: 10.1128/JVI.01272-14

FIG 7.

FIG 7

Proposed model for the function of VP24 in the regulation of genome replication and transcription and in morphogenesis. Genome replication and transcription of mRNAs take place using relaxed RNPs as the templates. VP24 leads to condensation of these RNPs, which locks the polymerase at the 3′ end of the genome and abolishes replication and transcription. For short minigenomes, both relaxed and condensed RNPs can be incorporated into trVLPs and infect target cells; however, only in condensed RNPs is the polymerase in the correct position to initiate primary transcription. For long minigenomes or full-length genomes, packaging of relaxed RNPs into particles is less efficient than for that of condensed RNPs due to their increased length, and infection of target cells with particles containing relaxed RNPs is less efficient than infection with trVLPs containing condensed particles.

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