Table 2.
Drug | Kd | ΔGobinding |
kT | ||
NPPB | 80 µM | −9.4 |
3NB | 9 mM | −4.7 |
3PP | 6 mM | −5.1 |
For NPPB, Kd was taken from Csanády and Töröcsik (2014). For 3NB and 3PP, Kd was estimated as the apparent K1/2 for stimulating open probability at −80 mV (Fig. 5, D and H), assuming voltage-independent binding at the gating site.