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. 2014 Oct;144(4):297–309. doi: 10.1085/jgp.201411245

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© 2014 Keum et al.

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Figure 2. — βARK-ct attenuates M₁ muscarinic receptor–induced inhibition of Ca_V2.2(β2a) currents. (A) Cells transfected with Ca_V2.2, α2δ1, and β2a in the presence and absence of βARK-ct were stimulated with Oxo-M, and the Ca_V2.2(β2a) current suppression was measured. (B) Voltage dependence of activation of the Ca_V2.2(β2a) channel before and during M₁ receptor stimulation with Oxo-M. Dashed line is the I-V relation during Oxo-M application, which is scaled to the peak amplitude of the control. (C) Superimposed Ca_V2.2(β2a) current traces a and b from A. In control, the b′ dashed trace is a scaled version of b. (D) Superimposed Ca_V2.2(β2a) and Ca_V2.2(β3) current traces for control and during the stimulation of M₁ receptor. Blue line in right panel shows the scaled trace of Ca_V2.2(β3) current after Oxo-M application (red). Note that during the Oxo-M application, activation of Ca_V2.2(β2a) channels (left) but not Ca_V2.2(β3) channels (right) is dramatically slowed.