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. 2014 Oct;144(4):297–309. doi: 10.1085/jgp.201411245

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© 2014 Keum et al.

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Figure 6. — Voltage-dependent muscarinic modulation disappears in Gβγ-insensitive chimeric Ca_V2.2(α1C-1B) channels. (A) Effects on Ca_V2.2(α1C-1B) (β2a) currents of M₁ and M₂ muscarinic receptor stimulation. The current amplitude was measured at 10 mV every 4 s. Insets show currents a and b superimposed. (B) Inhibition by Dr-VSP activation of Ca_V2.2(α1C-1B) (β2a) currents. Cells received a test pulse (a) and then were depolarized to 120 mV for 1 s, followed by a second test pulse (b). Current traces before and after the Dr-VSP activation in cells expressing the α1C-1B and β3 subunits are shown. (C) Summary of current suppression by muscarinic stimulation or Dr-VSP activation. (D) Current traces before (a) and during (b) the Oxo-M application (left and middle) or Dr-VSP activation (right) in cells expressing the α1C-1B and β3 subunits. Effects on Ca_V2.2(α1C-1B) (β3) currents of M₁ and M₂ muscarinic receptor stimulation and Dr-VSP activation were traced as above. (E) Summary of current suppression by muscarinic stimulation or Dr-VSP activation. (C and E) Data are mean ± SEM (n = 5 for each bar).