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. 2014 Oct;144(4):311–320. doi: 10.1085/jgp.201411247

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© 2014 Lin et al.

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Figure 4. — Effects of mutations at Y1219 on the response of G551D-CFTR to ATP washout. (A–C) Real-time current traces in response to ATP removal for G551D/Y1219F (A), G551D/Y1219I (B), and G551D/Y1219G (C). (D) Summary of the ratios between the peak current after ATP washout (I_PEAK) and the steady-state current before ATP removal (I_ATP) for G551D and its variants. Mean ± SEM is shown.