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. 2014 Oct;144(4):311–320. doi: 10.1085/jgp.201411247

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© 2014 Lin et al.

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Figure 6. — A negative charge at position 551 is needed to confer the inhibitory effect of ATP on CFTR gating. (A–C) Responses to ATP withdrawal in different G551 mutants: G551S (A), G551K (B), and G551E (C). (D) A modified gating model with NBD-dimerized states crossed out for G551D-CFTR. CFTR’s TMDs and NBDs are marked in one of the cartoon representations of the CFTR protein: NBD1 in red and NBD2 in blue. “D” in the red star depicts the location of G551D in the tail subdomain of NBD1. As marked, the green circles denote the ligand ATP.