Table 3.
Mean Cytokine and Chemokine Levels at Baseline, at Three Months, and during a Disease Flare.*
| Cytokine or Chemokine Analytes | Baseline | 3 Mo | P Value† | Flare | P Value‡ |
|---|---|---|---|---|---|
| Interleukin-6 in serum (pg/ml) | 0.01 | 0.008 | |||
| Median | 5.70 | 3.96 | 20.73 | ||
| Interquartile range | 3.19–15.97 | 1.90–5.50 | 4.90–31.08 | ||
| Interleukin-6 in cerebrospinal fluid | 0.04 | NA | |||
| Median | 43.93 | 21.61 | ND | ||
| Interquartile range | 26.19–93.37 | 7.76–68.90 | ND | ||
| TNF (pg/ml) | 0.006 | 0.5 | |||
| Median | 556 | 318 | 403 | ||
| Interquartile range | 83–646 | 81–452 | 361–488 | ||
| TNF receptor (pg/ml) | 0.008 | 0.04 | |||
| Median | 1154 | 650 | 889 | ||
| Interquartile range | 638–1459 | 412–1377 | 582–1215 | ||
| Stromal-cell–derived factor 1 (pg/ml) | 0.002 | 0.3 | |||
| Median | 1125 | 875 | 962 | ||
| Interquartile range | 385–2948 | 379–1111 | 349–1199 | ||
| E-selectin (ng/ml) | 0.002 | 0.2 | |||
| Median | 134 | 45 | 88 | ||
| Interquartile range | 80–196 | 41–61 | 43–105 | ||
| Interleukin-1–receptor antagonist in serum (pg/ml) | <0.001 | 0.001 | |||
| Median | 364 | 43,237 | 466 | ||
| Interquartile range | 232–1255 | 8795–200,300 | 208–763 | ||
| Interleukin-1–receptor antagonist in cerebrospinal fluid (pg/ml) | <0.001 | NA | |||
| Median | 211 | 1,136 | ND | ||
| Interquartile range | 77–352 | 497–1686 |
*
ND denotes not done, and NA denotes not applicable.
†
P values are for the comparison of baseline values with values obtained at three months.
‡
P values are for the comparison of values at three months with values obtained during a disease flare at two to seven days after withdrawal of anakinra.