A, Patient with CFC (BRAF p.Q257R missense mutation) at (from left to right) 4 days, 3 months, 3 years, 5 years, 7 years, 12 years, 14 years, and 16 years. B, Patient with CFC (MEK2 p.F57C missense mutation) at (from left to right) 1 day, 3 years, 7 years, 9 years, 13 years, 14 years, 16 years, and 20 years.