TABLE 2.
CD4% Outcomes at 4 Years, Comparing WHO Immunodeficiency Classification None, Mild, Advanced Versus Severe Suppression
| Baseline WHO Immune Deficiency Classification | Unadjusted | Adjusteda | Unadjusted | Adjusteda | ||||
|---|---|---|---|---|---|---|---|---|
| CD4% Mean (95% CI) | Difference vs Severeb Mean (95% CI) | CD4% Mean (95% CI) | Difference vs Severeb Mean (95% CI) | Proportion Normal % (95% CI) | Difference vs Severec % (95% CI) | Proportion Normal % (95% CI) | Difference vs Severec % (95% CI) | |
| None, n = 37 | 40.0 (37.4 to 42.6) | 11.0 (7.8 to 14.1) | 38.5 (36.5 to 40.4) | 9.4 (6.7 to 12.0) | 95% (87% to 100%)d | 48% (35% to 61%) | 90% (81% to 99%) | 43% (29% to 57%) |
| Mild, n = 27 | 35.3 (32.3 to 38.4) | 6.3 (2.8 to 9.8) | 35.1 (32.8 to 37.3) | 5.9 (2.9 to 9.0) | 78% (62% to 93%) | 32% (12% to 51%) | 77% (60% to 94%) | 30% (10% to 50%) |
| Advanced, n = 38 | 32.1 (29.6 to 34.7) | 3.1 (0.0 to 6.2) | 33.1 (30.6 to 35.5) | 3.9 (0.8 to 7.0) | 63% (48% to 78%) | 17% (–2% to 36%) | 66% (50% to 81%) | 19% (0% to 38%) |
| Severe, n = 80 | 29.0 (27.3 to 30.8) | Reference | 29.1 (27.3 to 31.0) | Reference | 46% (35% to 57%) | Reference | 47% (36% to 58%) | Reference |
a
Adjusted for age, gender, and race. Mean CD4% and proportion normal are estimated at the covariate distribution of secondary outcomes subset (mean age 5.8 y).
b
Unadjusted P < .001, adjusted P < .001.
c
Unadjusted P < .001, adjusted P < .001.
d
Wald upper 95% confidence limits exceeding 100% were rounded to 100%.