Table 2.

Morphometric Parameters According to Graft Failure Status

Graft Failure Status	Endothelial Cell Density (cells/mm2)			Coefficient of Variation			Percent Hexagonality
	N	Median (Quartiles)	P value*	N	Median (Quartiles)	P value*	N	Median (Quartiles)	P value*
Baseline**
Graft Failure	14	2526 (2385, 2969)	0.43	14	0.33 (0.29, 0.36)	0.91	14	61% (54%, 65%)	0.86
Non-failure	54	2664 (2418, 2905)		54	0.33 (0.31, 0.36)		54	59% (55%, 64%)
6 Months
Subsequent Graft Failure	11	1752 (1234, 2558)	0.004	11	0.25 (0.23, 0.28)	0.91	11	57% (50%, 63%)	0.02
Non-failure	35	2394 (2005, 2649)		35	0.25 (0.23, 0.28)		35	63% (57%, 70%)
6 month relative change*** from baseline
Subsequent Graft Failure	10	–24% (–53%, –5%)	0.005	10	–26% (–39%, –18%)	0.44	10	–1% (–10%, +18%)	0.17
Non-failure	35	–10% (–28%, 0%)		35	–23% (–30%, –13%)		35	+11% (–2%, +16%)

^*P values are generated from univariate Cox models fitted with the continuous morphometric parameters at baseline and 6 months. The models with the 6 month parameters and the 6 month relative change are conditional on graft survival by 6 months.

^**One of the 69 baseline images available for morphometric analysis, was non-gradable.

^***Calculated as the difference between the morphometric values at 6 month and baseline divided by the baseline value. The relative change is expressed as percentage with negative sign indicating loss of cells (for endothelial cell density), decreased HEX or CV.