Fig. 5.

Effects of gintonin on I_hERG, I_tail, and slow Ideactivating-tail. (A) Representative current trace showing hERG K⁺ channel enhancement by gintonin (10 μg/ml). Currents were in response to 4-s voltage steps to 0 mV from a holding potential of −90 mV, followed by repolarization to −60 mV. (B) I–V relationship for hERG K⁺ currents measured at the end of the 4-s test pulse before and after application of 10 μg/ml gintonin (n = 5). Currents were normalized to the control current at 0 mV for each oocyte. Data are represented as mean ± S.E.M. (n = 7).