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. 2014 Sep 18;37(9):656–663. doi: 10.14348/molcells.2014.0087

Fig. 8.

Fig. 8.

Diagram comparing gintonin- and ginsenoside Rg3-mediated activation of the IKs channel. Gintonin-mediated IKs activation proceeds via Ca2+/CaM binding to IQ motifs via G protein-coupled LPA1 receptors, whereas ginsenoside Rg3 activates IKs through a direct interaction with specific amino acids located at the pore entryway of channel proteins following depolarization (Choi et al., 2010).