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LC50 values for statins with and without mevalonate in differentiated RD cells treated with uremic toxins
| LC50 Values (95% Confidence Interval) | ||||
|---|---|---|---|---|
| PRV (µM) | PRV (µM) + Mevalonate (µM) | SIM (µM) | SIM (µM) + Mevalonate (µM) | |
| Untreated | 898 (857–940) | N.C. | 2.23 (2.15–2.31) | 105 (103–106) |
| Four uremic toxins | 814 (786–842) * | N.C. | 1.97 (1.89–2.04) * | 103 (102–104) |
Notes: PRV, pravastatin; SIM, simvastatin. * Non-overlapping 95% confidence intervals, vs. untreated cells; N.C., not Calculated.
