Table 2.
Urine volumes and fecal excretion in intact normoglycemic and db/db mice.
| Groups | Urine Volume (mL/24 h/Mouse): Days after Initial Treatment | Fecal Excretion (g/24 h/Mouse): Days after Initial Treatment | ||||
|---|---|---|---|---|---|---|
| 28 | 63 | 83 | 28 | 63 | 83 | |
| Controls | ||||||
| Intact | 1.53 ± 0.47 | 1.55 ± 0.23 | 1.54 ± 0.32 | 1.06 ± 0.32 | 1.12 ± 0.19 | 1.14 ± 0.17 |
| db | 9.91 ± 1.96 d | 16.84 ± 2.25 a | 17.78 ± 2.29 d | 1.39 ± 0.22 d | 1.40 ± 0.21 b | 1.40 ± 0.17 a |
| Reference | ||||||
| Metformin | 7.45 ± 1.85 df | 13.16 ± 1.70 ab | 13.69 ± 1.35 de | 1.75 ± 0.27 de | 1.77 ± 0.26 ab | 1.75 ± 0.25 ab |
| GT 400 mg/kg | 7.88 ± 1.32 d | 13.83 ± 2.01 ab | 14.39 ± 0.91 de | 1.69 ± 0.17 df | 1.71 ± 0.16 ab | 1.66 ± 0.17 ab |
| fGT treated | ||||||
| 400 mg/kg | 5.74 ± 1.21 deg | 7.39 ± 2.11 abc | 7.65 ± 2.38 deg | 2.04 ± 0.07 deg | 2.18 ± 0.22 abc | 2.13 ± 0.14 abc |
| 200 mg/kg | 5.86 ± 0.99 deg | 8.80 ± 1.79 abc | 9.19 ± 2.17 deg | 1.97 ± 0.16 deh | 2.01 ± 0.18 abc | 1.93 ± 0.14 abc |
| 100 mg/kg | 7.08 ± 2.10 df | 12.43 ± 2.96 ab | 14.68 ± 1.34 de | 1.75 ± 0.33 df | 1.75 ± 0.24 ab | 1.74 ± 0.25 ab |
Values are expressed mean ± S.D. of eight mice. GT, Green tea aqueous lyophilized extracts; fGT, Aquilariae Lignum-fermented green tea aqueous lyophilized extracts; metformin was administrated at a dose level of 250 mg/kg; a p < 0.01 as compared with intact control by LSD test; b p < 0.01 as compared with db control by LSD test; c p < 0.01 as compared with GT 400 mg/kg by LSD test; d p < 0.01 as compared with intact control by MW test; e p < 0.01; f p < 0.05 as compared with db control by MW test; g p < 0.01; h p < 0.05 as compared with GT 400 mg/kg by MW test.