Table 8.
Changes on serum biochemistry in intact normoglycemic and db/db mice.
| Groups | Controls | Reference | fGT Treated (mg/kg) | ||||
|---|---|---|---|---|---|---|---|
| Intact | db | Metformin | GT 400 mg/kg | 400 | 200 | 100 | |
| AST (IU/L) | 44.00 ± 19.26 | 453.00 ± 111.08 e | 283.00 ± 61.65 eg | 298.38 ± 66.02 eg | 160.75 ± 38.24 egi | 216.68 ± 39.96 egj | 271.50 ± 31.20 eg |
| ALT (IU/L) | 24.25 ± 6.18 | 191.13 ± 15.42 e | 150.13 ± 15.42 eg | 162.00 ± 13.86 eg | 83.13 ± 28.51 egi | 104.63 ± 17.86 egi | 153.25 ± 14.34 eg |
| BUN (mg/dL) | 29.88 ± 5.19 | 63.75 ± 16.21 e | 44.83 ± 5.85 eg | 47.38 ± 6.39 eh | 36.63 ± 4.93 fgi | 40.13 ± 2.17 egi | 44.25 ± 6.65 eg |
| Creatinine (mg/dL) | 0.64 ± 0.18 | 1.93 ± 0.36 a | 1.48 ± 0.21 ac | 1.49 ± 0.20 ac | 1.04 ± 0.21 acd | 1.14 ± 0.20 acd | 1.41 ± 0.18 ac |
| Glucose (mg/dL) | 120.63 ± 20.48 | 615.50 ± 86.67 a | 402.88 ± 62.99 ac | 461.50 ± 55.45 ac | 279.63 ± 104.50 acd | 329.50 ± 83.26 acd | 430.38 ± 64.38 ac |
| TC (mg/dL) | 120.50 ± 39.58 | 312.25 ± 38.34 e | 247.25 ± 11.99 eg | 266.00 ± 16.31 eg | 223.63 ± 16.54 egi | 236.88 ± 15.87 egi | 257.50 ± 20.47 eg |
| TG (mg/dL) | 85.25 ± 12.31 | 232.25 ± 23.32 a | 162.25 ± 18.58 ac | 175.38 ± 21.39 ac | 108.00 ± 16.20 bcd | 143.13 ± 21.24 acd | 165.00 ± 25.93 ac |
| LDL (mg/dL) | 11.50 ± 1.60 | 42.38 ± 5.45 e | 31.88 ± 5.64 eg | 32.38 ± 5.55 eg | 16.38 ± 4.14 fgi | 19.75 ± 2.12 egi | 28.75 ± 6.58 eg |
| HDL (mg/dL) | 68.13 ± 13.05 | 32.25 ± 10.15 e | 44.38 ± 5.01 eg | 43.00 ± 3.55 eg | 62.13 ± 8.32 gi | 56.88 ± 13.08 gj | 44.75 ± 5.85 eg |
Values are expressed as mean ± SD of eight mice. GT, Green tea aqueous lyophilized extracts; fGT, Aquilariae Lignum-fermented green tea aqueous lyophilized extracts; metformin was administrated at a dose level of 250 mg/kg; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; TC, total cholesterol; TG, triglyceride; LDL, low density lipoprotein; HDL, high density lipoprotein; a p < 0.01 and b p < 0.05 as compared with intact control by LSD test; e p < 0.01 and f p < 0.05 as compared with intact control by MW test; c p < 0.01 as compared with db control by LSD test; g p < 0.01 and h p < 0.05 as compared with db control by MW test; d p < 0.01 as compared with GT 400 mg/kg by LSD test; i p < 0.01 and j p < 0.05 as compared with GT 400 mg/kg by MW test.