Table 9.
Changes on the liver lipid peroxidation and antioxidant defense systems in intact normo-glycemic and db/db mice.
| Groups | Lipid Peroxidation | Antioxidant Defense System | ||
|---|---|---|---|---|
| Malondialdehyde (nM/mg Tissue) | Glutathion (μM/mg Tissue) | Catalase (U/mg Tissue) | SOD (U/mg Tissue) | |
| Controls | ||||
| Intact | 17.47 ± 2.32 | 28.24 ± 4.76 | 17.46 ± 3.34 | 2.13 ± 0.29 |
| db | 66.09 ± 15.87 d | 10.31 ± 2.27 d | 8.17 ± 1.46 d | 0.71 ± 0.24 a |
| Reference | ||||
| Metformin | 43.73 ± 5.09 df | 14.10 ± 2.48 df | 10.82 ± 1.21 df | 1.04 ± 0.12 ab |
| GT 400 mg/kg | 45.62 ± 8.21 df | 15.55 ± 2.31 df | 11.83 ± 1.72 df | 1.11 ± 0.13 ab |
| fGT treated | ||||
| 400 mg/kg | 26.49 ± 7.82 dfh | 24.52 ± 5.05 fh | 15.99 ± 1.72 fh | 1.55 ± 0.18 abc |
| 200 mg/kg | 33.45 ± 6.97 dfi | 19.37 ± 1.35 dfh | 15.39 ± 1.91 fh | 1.43 ± 0.14 abc |
| 100 mg/kg | 43.03 ± 12.77 dg | 16.23 ± 2.99 df | 12.44 ± 3.77 eg | 1.16 ± 0.25 ab |
Values are expressed as mean ± SD of eight mice. GT, Green tea aqueous lyophilized extracts; fGT, Aquilariae Lignum-fermented green tea aqueous lyophilized extracts; metformin was administrated at a dose level of 250 mg/kg; SOD, superoxide dismutase; a p < 0.01 as compared with intact control by LSD test; b p < 0.01 as compared with db control by LSD test; c p < 0.01 as compared with GT 400 mg/kg by LSD test; d p < 0.01 and e p < 0.05 as compared with intact control by MW test; f p < 0.01 and g p < 0.05 as compared with db control by MW test; h p < 0.01 and i p < 0.05 as compared with GT 400 mg/kg by MW test.