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. Author manuscript; available in PMC: 2015 Sep 18.
Published in final edited form as: Chem Biol. 2014 Sep 18;21(9):1102–1114. doi: 10.1016/j.chembiol.2014.09.001

Figure 1.

Figure 1

PPI can be classified by whether one side of the interface consists of a primary (linear) protein sequence (green), a single region of secondary structure (such as an alpha helix, yellow), or multiple sequences requiring tertiary structure (red). There are fewer examples of small-molecule inhibitors of PPI as the interface becomes more complex (from primary, to secondary, to tertiary epitopes).Structures shown are BRDt/histone (green, 2WP1), MDM2/p53 (yellow, 1YCR), and IL-2/IL-2Ra (red, 1Z92).