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. Author manuscript; available in PMC: 2015 Sep 18.
Published in final edited form as: Chem Biol. 2014 Sep 18;21(9):1102–1114. doi: 10.1016/j.chembiol.2014.09.001

Figure 4.

Figure 4

BCL-2/BCL-xL and MDM2 interfaces contain secondary epitopes. A) Structure of BCL-2 (white surface) bound to ABT-199 (green sticks, PDB: 4MAN) with overlaid BAX BH3 peptide (magenta cartoon, PBD: 2XA0). Chemical structures of selected BCL-2 and BCL-xL inhibitors. B) Structure of MDM2 (white surface) bound to RG-7112 (green sticks, PDB: 4IPF) with overlaid p53 peptide (magenta cartoon, PDB: 1YCR). Chemical structures of compounds in clinical testing or their closest published analogs.