Table 3. The top 15 Side Effects of Methadone Maintenance Subjects (N=366).

	Overall N=366			Urine Morphine Positive N=185			Urine Morphine Negative N=178			P-valuea	P-valueb
	n	%	Mean ± SD	n	%	Mean ± SD	n	%	Mean ± SD
Constipation	248	67.80%	1.96 ± 0.84	125	67.60%	2.01 ± 0.85	121	68.00%	1.92 ± 0.83	0.4	0.93
Sedation	172	47.00%	1.51 ± 0.70	94	50.80%	1.51 ± 0.68	77	43.30%	1.49 ± 0.72	0.73	0.15
Change in Libido	111	30.30%	1.72 ± 0.79	63	34.10%	1.70 ± 0.75	47	26.40%	1.77 ± 0.84	0.76	0.11
Dry Mouth	101	27.60%	1.55 ± 0.70	59	31.90%	1.61 ± 0.74	41	23.00%	1.49 ± 0.64	0.49	0.06
Excessive Sweating	71	19.40%	1.86 ± 0.85	38	20.50%	1.95 ± 0.87	32	18.00%	1.75 ± 0.84	0.34	0.54
Insomnia	67	18.30%	1.93 ± 0.78	32	17.30%	2.03 ± 0.78	34	19.10%	1.85 ± 0.78	0.36	0.66
Impaired Mentation	79	21.60%	1.61 ± 0.72	41	22.20%	1.78 ± 0.76	37	20.80%	1.43 ± 0.65	0.032	0.75
Fatigue	65	17.80%	1.62 ± 0.78	32	17.30%	1.78 ± 0.79	32	18.00%	1.47 ± 0.76	0.08	0.87
Difficulty with Urination	52	14.20%	1.38 ± 0.60	28	15.10%	1.50 ± 0.69	23	12.90%	1.26 ± 0.45	0.24	0.54
Increase in Appetite	46	12.60%	1.48 ± 0.59	25	13.50%	1.52 ± 0.51	21	11.80%	1.43 ± 0.68	0.37	0.62
Decrease in Appetite	44	12.00%	1.55 ± 0.70	26	14.10%	1.50 ± 0.71	18	10.10%	1.61 ± 0.70	0.54	0.25
Weight Gain	38	10.40%	1.68 ± 0.74	18	9.70%	1.67 ± 0.59	20	11.20%	1.70 ± 0.86	0.86	0.64
Weakness	33	9.00%	1.36 ± 0.70	18	9.70%	1.56 ± 0.86	14	7.90%	1.14 ± 0.36	0.17	0.53
Malaise	27	7.40%	1.48 ± 0.64	13	7.00%	1.62 ± 0.65	13	7.30%	1.38 ± 0.65	0.31	0.92
Tachycardia/Palpitations	25	6.80%	1.44 ± 0.71	14	7.60%	1.43 ± 0.65	10	5.60%	1.50 ± 0.85	1.00	0.45

Values are shown as mean ± SD or n, %.

Bold P-value: P<0.05.

^aWilcoxon rank-sum test.

^bChi-Square test.