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. 2014 Sep 8;3:e01913. doi: 10.7554/eLife.01913

Figure 4. Raptor deletion in hematopoietic cells results in hypochromic microcytic anemia and perinatal lethality.

(A) Embryos dissected at E16.5 illustrating the pallor of VavCreRaptorfl/fl (RAP-KO) mice relative to littermate controls. (B) Complete blood counts from the fetal liver of E17 RAP-KO embryos and littermate controls. (C) Western blotting for the level of α-globin and actin in RAP-KO mice or littermate controls. (D) Quantification of the percentage of fetal liver cells corresponding to various erythroid progenitors at E16.5 by flow cytometry. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

DOI: http://dx.doi.org/10.7554/eLife.01913.007

Figure 4.

Figure 4—figure supplement 1. Newborn RAP-KO pups are extremely pale.

Figure 4—figure supplement 1.

Picture of RAP-KO pup (left) and normal littermate (right) within 1 hr of birth.
DOI: http://dx.doi.org/10.7554/eLife.01913.008