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. Author manuscript; available in PMC: 2014 Sep 30.
Published in final edited form as: Mol Psychiatry. 2013 Dec 10;19(5):580–587. doi: 10.1038/mp.2013.167

Figure 4.

Figure 4

Glutamic acid decarboxylase 1 (GAD1) suppression has cell type-specific augmentation or attenuation of amphetamine (AMPH)-induced locomotion. All mice displayed increased locomotor activity in response to a 3 mg kg −1 injection of amphetamine. AMPH sensitivity was defined as the magnitude of the locomotor response after AMPH injection relative to baseline locomotor activity. NPYGAD1TG mice were ~600% more sensitive to AMPH compared with wild-type (WT) littermate controls, whereas CCKGAD1TG mice were ~50% less sensitive (a). Total locomotor activity across the entire post-injection session was decreased in CCKGAD1TG mice and increased in NPYGAD1TG mice compared with WT littermate controls (b). **P < 0.01; *P < 0.05.