Table 2.
Chromosome |
Base Pair |
Reference Allele |
Alternate Allele |
dbSNP Identifier |
SNV vs. Insertion/ Deletion (Indel) |
Alternate Allele Frequency |
Odds Ratio |
Confidence Range |
P |
|
Fuchs' |
Control |
|||||||||
18 | 53210302 | G | T | rs613872 | SNV | 0.4779 | 0.125 | 12.04 | 3.2–47.2 | 0.0004 |
18 | 53244414 | A | T | rs2924322 | SNV | 0.3731 | 0.1 | 10.25 | 2.1–49.2 | 0.004 |
18 | 53244442 | TAA | T | rs33980799 | Indel | 0.375 | 0.125 | 7.0 | 1.8–26.9 | 0.005 |
18 | 53248151 | T | C | rs618869 | SNV | 0.375 | 0.125 | 7.0 | 1.8–26.9 | 0.005 |
18 | 53264343 | A | G | rs596668 | SNV | 0.375 | 0.125 | 7.0 | 1.8–26.9 | 0.005 |
18 | 53252388 | G | A | rs599550 | SNV | 0.375 | 0.1562 | 7.0 | 1.8–26.9 | 0.005 |
18 | 53308061 | AT | A | rs59006454 | Indel | 0.6912 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53276116 | T | A | rs12458118 | SNV | 0.6912 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53276523 | G | A | rs9951280 | SNV | 0.6912 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53299460 | G | A | rs12103984 | SNV | 0.6912 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53315397 | T | A | rs17089911 | SNV | 0.6912 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53270531 | T | C | rs682245 | SNV | 0.6912 | 0.4688 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53292908 | T | C | rs8090341 | SNV | 0.6985 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53296927 | G | A | rs12457157 | SNV | 0.6985 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53301527 | A | C | rs6566169 | SNV | 0.6985 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53303546 | T | G | rs35691742 | SNV | 0.6985 | 0.4375 | 7.273 | 1.7–31.4 | 0.008 |
18 | 53186092 | T | C | rs627685 | SNV | 0.7868 | 0.5938 | 7.615 | 1.2–50.2 | 0.035 |
18 | 53204136 | A | C | rs658905 | SNV | 0.5147 | 0.4375 | 3.291 | 1.0–10.5 | 0.044 |
18 | 52904858 | G | GC | rs36069440 | Indel | 0.2721 | 0.09375 | 3.852 | 1.0–14.7 | 0.049 |
18 | 53178061 | G | A | rs67387556 | SNV | 0.6176 | 0.625 | 4.2 | 1.0–18.0 | 0.053 |
18 | 53284109 | A | G | rs616580 | SNV | 0.3088 | 0.5625 | 0.2923 | 0.1–1.1 | 0.073 |
18 | 53287570 | C | T | rs1642313 | SNV | 0.3088 | 0.5625 | 0.2923 | 0.1–1.1 | 0.073 |
18 | 53294569 | T | C | rs644279 | SNV | 0.3088 | 0.5625 | 0.2923 | 0.1–1.1 | 0.073 |
18 | 53193029 | C | CT | rs11441646 | Indel | 0.4853 | 0.4062 | 2.748 | 0.9–8.6 | 0.083 |
18 | 53190188 | G | A | rs9948513 | SNV | 0.4853 | 0.4062 | 2.748 | 0.9–8.6 | 0.083 |
A dominant model association test was performed for each variant shown. Logistic regression statistics and odds ratios for FECD are shown for the 25 variants with the lowest P values. The SNV that confers the highest odds ratio for FECD is rs613872, with an odds ratio of 12 in these samples.