Table 1.

Swimming and Paralytic Measurements

	Maximal Frequency (Hz)	Latency to Paralyze (sec)	Reversion IncidenceA	Reversion Frequency (events/animal)	Reversion ProbabilityB	Time to 1st Reversion (sec)	Average Reversion Event Length (sec)
N2(n=63)	1.82+/−0.141	305+/−165	0.455	3.80 +/−1.93	1070+/−693	93.9+/−132	17.5+/−24.0
N2 + 3 μM IMI(46)	1.60+/−0.262***	274+/−141	0.25	3.33+/−3.21	432+/−584	147+/−89.8	20.0+/−31.5
N2 + 10 μM IMI(38)	1.65+/−0.137***	297+/−169	0.2	1.25+/−0.50	42.7+/−52.3*	175+/−97.0	7.62+/−8.79
dat-1(ok157)(117)	1.46+/−0.436	206+/−124	0.366	0.336+/−2.63	394+/−500	140+/−127	13.4+/−26.6
dat-1 + 3 μM IMI(31)	1.61+/−0.193	261+/−109	0.308	1.38+/−0.744	237+/−417	171+/−121	5.36+/−6.20
dat-1 + 10 μM IMI(27)	1.56+/−0.260	260+/−141	0.273	0.273+/−2.33	162+/−264	235+/−84.2	6.40+/−3.19
cat-2(tm2261)(38)	1.75+/−0.091	N/A	N/A	N/A	N/A	N/A	N/A
cat-2 + 3 μM IMI(23)	1.82+/−0.097	438+/−138	0.333	0.333+/−3.5	0.333+/−3.50	177+/−44.3	1.15+/−0.54
cat-2 + 10 μM IMI(27)	1.53+/−0.183***	140+/68.3**C	0.25	9	715	98.2	5.87
dop-3(vs106)(22)	1.88+/−0.034	223+/−206	1	2.67+/−1.15	1500+/−1550	157+/−139	15.89+/−10.0
dop-3 + 3 μM IMI(27)	1.81+/−0.050	379+/−165	0.333	0.333+/−2.00	986+/−1380	50.1+/−3.15	9.08+/−12.8
dop-3 + 10 μM IMI(34)	1.50+/−0.278***	188+/−144	0D*	N/A	N/A	N/A	N/A

^AReversion Probability = total time spent in reversion/total time after paralysis onset

^BReversion Incidence = fraction of animals that reverse from paralysis

Asterisks(*) indicate a significant difference to control genotype as determined by one-way ANOVA with Dunnet’s multiple comparision test where

^*p < 0.05,

^**p < 0.01, and

^***p < 0.001.

^Cunpaired student’s t test to cat-2 + 3 μM IMI

^DChi-square test