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. 2014 Sep 22;463(Pt 2):167–176. doi: 10.1042/BJ20140741

Figure 7. Current signals developed by ATP7A on a solid supported membrane in the presence of cisplatin or oxaliplatin.

Figure 7

Representative current transients induced by ATP (100 μM) concentration jumps in the presence of: CuCl2 (5 μM, black lines), cisplatin or oxaliplatin (5 μM, red lines), a mixture of CuCl2 and cisplatin or oxaliplatin (5 μM of each, green lines), and a mixture of CuCl2 and cisplatin or oxaliplatin (5 μM of each) with a copper chelator (1 mM BCS, blue lines). Adapted from [71]. Translocation of platinum anticancer drugs by human copper ATPases ATP7A and ATP7B. Tadini-Buoninsegni, F., Bartolommei, G., Moncelli, M. R., Inesi, G., Galliani, A., Sinisi, M., Losacco, M., Natile, G. and Arnesano, F. Angew. Chem. Int. Ed. Engl. 53, Issue 5. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.