Table 4. KEGG pathways annotation of abnormal miRNA target genes.
| Pathway | MAPP name | Enrichment Score |
|---|---|---|
| mmu00562 | Inositol phosphate metabolism | 3.988221 |
| mmu04070 | Phosphatidylinositol signaling system | 3.533671 |
| mmu05410 | Hypertrophic cardiomyopathy (HCM) | 2.394271 |
| mmu04725 | Cholinergic synapse | 2.227839 |
| mmu05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.126784 |
| mmu04724 | Glutamatergic synapse | 2.109772 |
| mmu03460 | Fanconi anemia pathway | 2.017738 |
| mmu05142 | Chagas disease (American trypanosomiasis) | 2.010757 |
| mmu04150 | mTOR signaling pathway | 1.906663 |
| mmu04660 | T cell receptor signaling pathway | 1.713143 |
| mmu05322 | Systemic lupus erythematosus | 12.6937 |
| mmu04640 | Hematopoietic cell lineage | 6.723747 |
| mmu05034 | Alcoholism | 6.20107 |
| mmu05152 | Tuberculosis | 5.152889 |
| mmu04662 | B cell receptor signaling pathway | 4.675411 |
| mmu05202 | Transcriptional misregulation in cancer | 4.643977 |
| mmu04672 | Intestinal immune network for IgA production | 4.281526 |
| mmu04380 | Osteoclast differentiation | 4.255375 |
| mmu05150 | Staphylococcus aureus infection | 3.867061 |
| mmu05340 | Primary immunodeficiency | 3.857659 |
Notes.
a
Gray indicates downregulated target genes in the KEGG pathway.
b
In differentially expressed genes, 15 miRNA target genes were enriched into T cell receptor (TCR) signaling pathway (Fig. 3).