Table 1.
Specific NMDAR binding densities in repeatedly stressed and non-stressed WT and Nrg1 HET mice.
| Brain | WT | Nrg1 HET | Two-Way ANOVA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regions | No Stress | Stress | No Stress | Stress | Genotype | Condition | G × E | |||||||
| Mean | s.e.m. | Mean | s.e.m. | Mean | s.e.m. | Mean | s.e.m. | F-value | p-value | F-value | p-value | F-value | p-value | |
| PrL | 314.975 | ±26.642 | 342.732 | ± 22.813 | 349.642 | ±13.966 | 308.860 | ±23.018 | F(1, 18) = 0.0004 | 0.986 | F(1, 18) = 0.090 | 0.768 | F(1, 18) = 2.493 | 0.132 |
| IL | 297.697 | ±31.497 | 347.315 | ±23.179 | 348.422 | ±21.457 | 295.171 | ±19.492 | F(1, 18) = 0.001 | 0.977 | F(1, 18) = 0.006 | 0.941 | F(1, 18) = 4.527 | 0.047 |
| rCPu | 160.311 | ±18.842 | 200.519 | ±9.704 | 169.193 | ±11.588 | 160.594 | ±11.154 | F(1, 19) = 1.469 | 0.240 | F(1, 19) = 1.523 | 0.232 | F(1, 19) = 3.630 | 0.072 |
| M1-M2 | 247.933 | ±16.090 | 264.826 | ±9.768 | 236.519 | ±11.668 | 224.474 | ±20.893 | F(1, 19) = 3.223 | 0.088 | F(1, 19) = 0.028 | 0.868 | F(1, 19) = 1.007 | 0.328 |
| ACC | 291.354 | ±26.510 | 324.255 | ±16.283 | 281.255 | ±11.494 | 262.916 | ±14.381 | F(1, 20) = 3.744 | 0.067 | F(1, 20) = 0.156 | 0.697 | F(1, 20) = 1.926 | 0.181 |
| RSG | 171.369 | ±11.506 | 169.808 | ±14.702 | 143.954 | ±9.942 | 184.995 | ±16.380 | F(1, 20) = 0.207 | 0.654 | F(1, 20) = 2.156 | 0.158 | F(1, 20) = 2.511 | 0.129 |
| LSV | 127.992 | ±19.497 | 176.069 | ±14.489 | 128.175 | ±7.725 | 146.736 | ±10.233 | F(1, 19) = 1.068 | 0.314 | F(1, 19) = 5.584 | 0.029 | F(1, 19) = 1.095 | 0.308 |
| CA1 | 610.541 | ±27.062 | 619.457 | ±17.838 | 640.685 | ±23.267 | 678.384 | ±35.213 | F(1, 20) = 3.072 | 0.095 | F(1, 20) = 0.842 | 0.367 | F(1, 20) = 0.321 | 0.577 |
| CA3 | 459.248 | ±42.928 | 458.411 | ±41.408 | 416.045 | ±23.161 | 443.388 | ±32.370 | F(1, 19) = 0.640 | 0.434 | F(1, 19) = 0.133 | 0.720 | F(1, 19) = 0.150 | 0.703 |
| DG | 111.176 | ±10.369 | 137.475 | ±13.169 | 90.114 | ±6.194 | 153.924 | ±13.829 | F(1, 20) = 0.041 | 0.842 | F(1, 20) = 15.510 | 0.0008 | F(1, 20) = 2.688 | 0.117 |
Data expressed as mean fmol/mg tissue ± s.e.m. for all brain regions examined (n = 5–7/group). Significant values are highlighted in bold. PrL, prelimbic cortex; IL, infralimbic cortex; rCPu, rostral caudate putamen; M1-M2, motor cortex; ACC, anterior cingulate cortex; LSV, ventrolateral septum; RSG, retrosplenial granular cortex; DG, dentate gyrus; CA1 and CA3 subregions of the hippocampus.