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. 2014 Sep 29;2:38. doi: 10.3389/fbioe.2014.00038

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Copyright © 2014 Muller, Marzi and Nicassio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IsomiRs distribution at genome-wide level. (A) The bar graph shows the percentage of detected IsomiRs (>1 read counts) in the normal and tumor samples, divided in classes, as in Figure 6 (T, templated; NT, non-templated). The absolute number of species is also reported within the bar. (B) Bar graph shows the expression levels (total reads) of the each class. (C) Those miRNAs robustly detected (total read count for all isoforms >100 reads) were selected. Within each miRNA species, we calculated whether the selected isoform type contributes for at least a given percentage over the total reads of each miRNA.