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. 2014 Aug 22;28(10):1740–1751. doi: 10.1210/me.2014-1147

Figure 1.

Figure 1.

A, GWAS Manhattan plot GWAS performed with P values adjusted for age, previous fracture, bisphosphonate use, and the first 3 eigenvectors. The 3 SNP signals that underwent functional genomic validation are highlighted. B, LocusZoom plot of the chromosome 20 region surrounding the THIL-TUBB1-CTSZ-SLMO2-ATP5E genes showing a plot of −log10 (P values) for observed (circles) and imputed SNPs (diamonds). C, LocusZoom plot of the chromosome 6 region surrounding the TRAM2-TMEM14A genes. D, LocusZoom plot of the chromosome 2 region surrounding the MAP4K4 gene.