Table I.

Collective Stability Data Of Vancomycin Niosomes During Storage In Their Original Solution at 4^°C for 12 months

Time (month)	Vesicle mean diameter, nma	Vancomycin EE (%)b	Vesicle-associated Tween 40b (mg/5 mL)	Percentage of vancomycin release at 2 ha	Percentage of vancomycin release at 24 ha
Zero time	820 ± 60	49.8 ± 1.73	83.5 ± 2.71	55 ± 2.04	72 ± 1.96
3	720 ± 30	49.4 ± 0.85	84.3 ± 4.89	NDc	ND
6	750 ± 40	48.9 ± 0.32	80.1 ± 1.40	50 ± 2.40	74 ± 2.23
9	640 ± 40	50.4 ± 1.14	ND	ND	ND
12	400 ± 40	51.7 ± 1.12	82.6 ± 1.80	50 ± 2.54	72 ± 1.79

^aValues represent mean ± SD (n = 2)

^bValues represent mean ± SD (n = 3)

^c ND not determined