Table V.
Comparison of Drug Release Rate and 3-Point Dissolution Data for Ethylcellulose Coated HCTZ Matrix Tablets at Different Agitation Rates (Zero-Order Kinetics/Linear Equation), (a) Starch 1500 Formulation; (b) Lactose Formulation
| 50 rpm | 100 rpm | 150 rpm | |
|---|---|---|---|
| (a) Coated matrix - Starch 1500 formulation | |||
| k (Release rate, %/h) | 7.3 | 7.3 | 7.3 |
| R 2 (Correlation coefficient) | 0.9983 | 0.9983 | 0.9971 |
| t 10% (h) | 4.4 | 3.0 | 2.6 |
| t 50% (h) | 9.6 | 8.4 | 7.6 |
| t 90% (h) | 15.0 | 14.0 | 13.0 |
| (b) Coated matrix - lactose formulation | |||
| k (Release rate, %/h) | 6.6 | 6.4 | 5.8 |
| R 2 (Correlation coefficient) | 0.9985 | 0.9947 | 0.9994 |
| t 10% (h) | 3.6 | 3.8 | 2.8 |
| t 50% (h) | 9.2 | 9.8 | 10.4 |
| t 90% (h) | 15.8 | 15.8 | 16.2 |