Table IV.
Permeation Parameters of Ginsenoside Rb1 from 1–7 Formula Across Pig Skin
| Formulations | J × 10−3 μg/(cm2/h) | P m × 10−3 cm/h | ER | |
|---|---|---|---|---|
| Formula 1 | 0.2% azone | 19.5 ± 1.3 | 3.37 ± 0.21 | 3.210 ± 0.234 |
| Formula 2 | 0.2% menthol | 12.3 ± 1.1 | 2.12 ± 0.15 | 2.019 ± 0.157 |
| Formula 3 | 0.4% azone | 83.8 ± 5.4 | 1.92 ± 0.11 | 1.828 ± 0.174 |
| Formula 4 | 0.4% menthol | 11.1 ± 0.9 | 1.92 ± 0.32 | 1.828 ± 0.143 |
| Formula 5 | 0.4% azone + 0.2% menthol | 103.9 ± 87.4* | 17.95 ± 1.51 | 17.095 ± 1.347* |
| Formula 6 | 0.4% azone + 0.4% menthol | 79.0 ± 6.3 | 13.65 ± 1.24 | 13.000 ± 1.132* |
| Formula 7 | Without enhancer | 6.1 ± 0.7 | 1.05 ± 0.09 | 1 |
J flux, P m permeability coefficient, ER enhancement ratio
*Statistically significant difference at P < 0.05, compared to the control group (formula 7)
**Statistically significant difference at P < 0.01, compared to the control group (formula 7)